For decades, Hermiticity was considered an immutable axiom of quantum mechanics, essential for ensuring real energies and unitary evolution. This perspective has shifted radically, driven by the realization that non-Hermitian Hamiltonians provide a powerful effective description of open quantum systems, granting access to unique phenomena such as Exceptional Points and the Non-Hermitian Skin Effect. In this Perspective, we chart the trajectory of this field, moving from its established foundations in single-particle, linear models to the emerging frontier of interacting many-body systems. We first clarify the physical origins of non-Hermitian dynamics, distinguishing between mean-field approximations, conditional "no-click" evolution, and exact Liouvillian dynamics. We then focus on the rich phenomenology arising from the interplay of non-Hermiticity and interactions. We discuss interaction-induced topological phases, the generalization of skin effects to the many-body Hilbert space, and the distinct signatures of dissipative quantum chaos and complexity. Finally, we highlight collective phenomena in nonlinear regimes, including skin solitons and dissipative phase transitions. We also comment on measurement-induced entanglement transitions and their relation to non-Hermitian spectra and topology. By synthesizing these diverse developments, we provide a roadmap for the future of non-Hermitian physics.